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Inheriting Alzheimer’s Disease: Alzheimer’s May Be Inherited from Your Mother Featured

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Alzheimers-womanThere has been growing evidence that if one of your parents has Alzheimer’s disease, the chances of inheriting can be several times higher than if your parents do not have Alzheimer’s. New evidence shows that the chances of inheriting Alzheimer’s disease from your mother are even higher than from your father.   The new study is published in the March 1, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.

“It is estimated that people who have first-degree relatives with Alzheimer’s disease are four to 10 times more likely to develop the disease themselves compared to people with no family history,” said Hornea

The study was supported by the National Institute on Aging and the National Institute of Neurological Disorders and Stroke.

For the study, 53 dementia-free people age 60 and over were followed for two years. Eleven participants reported having a mother with Alzheimer’s disease, 10 had a father with Alzheimer’s disease and 32 had no history of the disease in their family. The groups were given brain scans and cognitive tests throughout the study.

The researchers found that people with a mother who had Alzheimer’s disease had twice as much gray matter shrinkage as the groups who had a father or no parent with Alzheimer’s disease. Shrinking of the brain, or brain atrophy, occurs in Alzheimer’s disease. In addition, those who had a mother with Alzheimer’s disease had about one and a half times more whole brain shrinkage per year compared to those who had a father with the Alzheimer’s disease.

“Using 3-D mapping methods, we were able to look at the different regions of the brain affected in people with maternal or paternal ties to Alzheimer’s disease,” said study author Robyn Honea, DPhil, of the University Of Kansas School Of Medicine in Kansas City.

“In people with a maternal family history of the Alzheimer’s disease, we found differences in the break-down processes in specific areas of the brain that are also affected by Alzheimer’s disease, leading to shrinkage. Understanding how Alzheimer’s disease may be inherited could lead to better Alzheimer’s disease prevention and better Alzheimer’s disease treatment strategies.”

The study was supported by the National Institute on Aging and the National Institute of Neurological Disorders and Stroke.

Last modified on Monday, 02 July 2012 16:36
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