MyBestHealthPortal.net: Better Health Through Better Knowledge

Recent research has shown that model organisms and humans have sensory experiences can impact a wide range of health-related characteristics including type II diabetes, athletic performance and aging. Fruit flies and Nematode worms that were robbed of their ability to smell or taste, for example, lived substantially longer. However, the specific odors and sensory receptors that control this effect on aging were unknown.

Using molecular genetics in combination with behavioral and environmental manipulations, researchers at the University of Michigan, University of Houston, and Baylor College of Medicine through collaborative efforts have succeeded in identifying carbon dioxide (CO₂) as the first well-defined odorant capable of altering physiology and affecting aging. Flies incapable of smelling CO₂ live longer than flies with normal olfactory capabilities. These flies also have increased body fat and are resistant to stress.

To many insects, including fruit flies, CO₂ represents an ecologically important odor cue that indicates the presence of food (e.g. rotting fruit or animal blood) or neighbors in distress (it has been implicated as a stress pheromone). The researchers previously showed that merely sensing one's normal food source is capable of reversing the health and longevity benefits that are associated with a low calorie diet. They now establish that CO₂ is responsible for this effect.

"We are working hard to understand how sensory perception affects health, and our new result really narrows the playing field. Somehow these 50 or so neurons, whose primary job it is to sense CO₂, are capable of instigating changes that accelerate aging throughout the organism," says Scott Pletcher.

Sensory perception has been shown to impact aging in species that are separated by millions of years of evolution, suggesting that similar effects may be seen in humans. "For us, it may not be the smell of yeast, for example, or the sensing of CO₂ that affects how long we live, but it may be the perception of food or danger," says Pletcher. If so, a clever program of controlled perceptual experience might form the basis of a simple yet powerful program of disease prevention and healthy aging.